Synthesis of (2S,4S)-2-Carboxy-4-Pyrrolidine Acetic Acid, a Conformationally Constrained 2-Amino Adipic Acid Analogue

Article abstract of DOI:10.1016/S0040-4039(00)60445-8

(2S,4S)-2-carboxy-4-pyrrolidine acetic acid was synthesized from (S)-pyroglutamic acid in 26 percent overall yield by a regiospecific deprotonation of the N-methoxycarbonyl benzylester 4. Key Words: pyroglutamic acid, excitatory amino-acids, alkyl bromoacetate, sodium cyanoborohydride.