ANTI-OXIDATIVE AND ANTI-INFLAMMATORY CURCUMIN-RELATED PHENOLICS FROM RHIZOMES OF CURCUMA DOMESTICA

Article abstract of DOI:10.1016/0031-9422(93)85179-U

Two new natural phenolics were isolated from the rhizomes of Curcuma domestica along with four known curcuminoids.The structures of the former were determined to be 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-(1E,4E)-1,4-dien-3-one and 1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-penta-(1E,4E)-1,4-dien-3-one, respectively, by spectral data and syntheses.Anti-oxidant activity of the phenolics was determined by the inhibition of autoxidation of linoleic acid in a water-alcohol system.Anti-inflammatory activity of the isolated compounds was determined on mouse ears by using a tumour promoter, TPA (12-O-tetradecanoylphorbol-13-acetate) as an inducer. Key Word Index: Curcuma domestica; Zingiberaceae; rhizome; curcuminoid; phenolic; anti-inflammatory activity; antioxidant activity.