An efficient method for the synthesis of a novel leukotriene B4 receptor antagonist, ONO-4057, via Michael reaction of dihydroresorcinol

Article abstract of DOI:10.1055/s-1997-1079

A practical method for the synthesis of ONO-4057, a highly potent and orally active leukotriene B₄ (LTB₄) receptor antagonist, was developed. This method includes improved synthesis of a key intermediate, 1,3-dioxo-2-(2-ethoxycarbony lethyl)cyclohexane (6).