An efficient method for the synthesis of a novel leukotriene B4 receptor antagonist, ONO-4057, via Michael reaction of dihydroresorcinol

DOI: 10.1055/s-1997-1079

Source and publish data:

Synlett p. 1472 - 1474 (1997)

Update date:2022-07-31

Topics:

Authors:

Konno, Mitoshi

Nakae, Takahiko

Sakuyama, Shigeru

Imaki, Katsuhiro

Nakai, Hisao

Hamanaka, Nobuyuki

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Article abstract of DOI:10.1055/s-1997-1079

A practical method for the synthesis of ONO-4057, a highly potent and orally active leukotriene B₄ (LTB₄) receptor antagonist, was developed. This method includes improved synthesis of a key intermediate, 1,3-dioxo-2-(2-ethoxycarbony lethyl)cyclohexane (6).

Full text of DOI:10.1055/s-1997-1079

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Product name:3-(1-Chloro-2,6-dioxo-cyclohexyl)-propionic acid ethyl ester

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