Tetrapeptide Tachykinin Antagonists: Synthesis and Modulation of the Physicochemical and Pharmacological Properties of a New Series of Partially Cyclic Analogs

DOI: 10.1021/jm00063a015

Source and publish data:

Journal of Medicinal Chemistry p. 1654 - 1661 (1993)

Update date:2022-07-29

Topics: Synthesis Tetrapeptide Modulation Physicochemical Properties Pharmacological Properties

Authors:

Kucharczyk, Nathalie

Thurieau, Christophe

Paladino, Joseph

Morris, Angela D.

Bonnet, Jacqueline

et al. et al.

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Article abstract of DOI:10.1021/jm00063a015

We report on the synthesis and the pharmacological properties of a new series of tachykinin antagonists based on the pseudopeptide pharmacophore cyclo<-Abo-Asp(D-Trp-Phe-N(Me)Bzl)-> which contains the 2-azabicyclo<2.2.2>octane-3(S)-carboxylic acid (Abo) r

Full text of DOI:10.1021/jm00063a015

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