Synthesis of Pyrazolo[1,5-a]pyrimidines in the Reaction of 5-Amino- 3-arylpyrazoles with Methoxymethylene Meldrum's Acid Derivatives and Thermolysis of Their Pyrazolylaminomethylene Derivatives

Article abstract of DOI:10.1002/jhet.5570350112

A series of pyrazolo[1,5-a]pyrimidin-3-ones 3 was prepared from Meldrum's acid and 5-amino-3-arylpyrazoles 1 by cyclization in nitrobenzene of the corresponding 5-pyrazolylaminomethylene Meldrum's acid derivatives 2. The structure of pyrazolo[1,5-a]pyrimidin-3-ones and their precursors were determined by nmr measurements.