Synthesis of possible metabolites of 1-cyclopropyl-1,4-dihydro-6-fluoro- 5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (grepafloxacin, OPC-17116)

DOI: 10.1248/cpb.43.2246

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2246 - 2252 (1995)

Update date:2022-08-03

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Authors:

Morita Morita

Otsubo Otsubo

Matsubara

Ohtani Ohtani

Kawano Kawano

Ohmori Ohmori

Ohguro Ohguro

Uchida Uchida

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Article abstract of DOI:10.1248/cpb.43.2246

Grepafloxacin (1-cyclopropyl-1,4-dihydro-6-fluoro-5-methyl-7-(3-methyl-1- piperazinyl)-4-oxo-3-quinoline-carboxylic acid, OPC-17116) (1) exhibits potent and broad-spectrum in vitro and in vivo antibacterial activity. In order to identify the structures of

Full text of DOI:10.1248/cpb.43.2246

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