A Highly Stereoselective Glycosylation of 2-(Phenylselenenyl)-2,3-dideoxyribose Derivative with Thymine: Synthesis of 3'-Deoxy-2',3'-didehydrothymidine and 3'-Deoxythymidine

DOI: 10.1021/jo00292a006

Source and publish data:

Journal of Organic Chemistry p. 1418 - 1420 (1990)

Update date:2022-09-26

Topics:

Authors:

Chu, Chung K.

Babu, J. Ramesh

Beach, J. Warren

Ahn, Soon K.

Huang, Haoqiang

et al. et al.

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Article abstract of DOI:10.1021/jo00292a006

A highly stereoselective synthesis of 3'-deoxy-2',3'-didehydrothymidine (D4T) and 3'-deoxythymidine (D2T) was achieved from the condensation of 2-(phenylselenenyl)-2,3-dideoxyribose derivative and silylated thymine in the presence of trimethylsilyl triflate.

Full text of DOI:10.1021/jo00292a006

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