Dipeptide mimetics can substitute for the receptor activation domain resulting in highly potent analogues of hPTH(1-36) fragment

Article abstract of DOI:10.1016/0960-894X(96)00188-6

A series of hPTH(1-36) analogues were prepared to study the role of the first peptide bond between residues Ser¹-Val². Some of these analogues were found to show high affinity binding in intact opossum kidney (OK-1) cells and were very active in their ability to stimulate adenylate cyclase production in intact OK-1 cells, rat UMR106-06 osteosarcoma cells, and SaOS-2 human osteosarcoma cells.