Design, synthesis, and three-dimensional structural characterization of a constrained Ω-loop excised from interleukin-1α

Article abstract of DOI:10.1016/S0040-4020(01)90219-4

The cyclic peptide 1, containing a 2,7-disubstituted naphthalene spacer, was designed to mimic an exposed Ω-loop present in interleukin-1α, an important mediator of immune and inflammatory responses. The synthesis of this cyclic peptide was accomplished v