Synthesis and antitumor activities of water-soluble benzoylphenylureas

DOI: 10.1248/cpb.47.430

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 430 - 433 (1999)

Update date:2022-08-04

Topics:

Authors:

Okada, Hiroshi

Kato, Masanari

Koyanagi, Tohru

Mizuno, Kazuhiko

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Article abstract of DOI:10.1248/cpb.47.430

Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected intravenously.

Full text of DOI:10.1248/cpb.47.430

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Products guided by the article

Product name:1-(2-amino-benzoyl)-3-[4-(5-chloro-pyrimidin-2-yloxy)-3-trifluoromethyl-phenyl]-urea

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