
Tetrahedron Letters p. 6645 - 6648 (1987)
Update date:2022-08-03
Topics:
Tokoroyama, Takashi
Tsukamoto, Masamitsu
Asada, Toshihiro
Iio, Hideo
Doubly stereocontrolled cyclization of the allylsilane derivative 1 followed by trapping of the enolate with ClCH2SMe gives in one-pot manner the decalone derivative 5 in which all of the four contiguous diastereomeric centers of cis-clerodane skeleton have been secured.The total synthesis of linaridial 4 have been accomplished from 5.
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