Bakers' yeast oxidation of methyl para-tolylsulfide: Synthesis of a chiral intermediate in the preparation of the mevinic acid-type hypocholestemic agents

DOI: 10.1016/0040-4020(95)00819-T

Source and publish data:

Tetrahedron p. 13217 - 13238 (1995)

Update date:2022-07-30

Topics:

Authors:

Tang, Jenny

Brackenridge, Ian

Roberts, Stanley M.

Beecher, Jean

Willetts, Andrew J.

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Article abstract of DOI:10.1016/0040-4020(95)00819-T

The use of (R)-methyl-para-tolylsulfoxide as a chiral auxiliary in a novel synthesis of a key intermediate en route to mevinic acid-type hypocholestemic agents is described. The synthesis is short and simple consisting of eight steps to yield enantiomeric

Full text of DOI:10.1016/0040-4020(95)00819-T

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