Efficient synthesis of alamethicin F-30 using a chloro imidazolidium coupling reagent, CIP

Article abstract of DOI:10.1016/0040-4039(95)02023-I

Alamethicin F-30 has been synthesized in solution using a CIP-additive as a coupling agent and TFA as a final deprotecting reagent. All couplings including those between sterically hindered α,α-dimethyl amino acid were successfully achieved by a 60 min re