Transamination of Fluorinated β-Keto Carboxylic Esters. A Biomimetic Approach to β-Polyfluoroalkyl-β-amino Acids.

DOI: 10.1016/S0040-4039(00)73652-5

Source and publish data:

Tetrahedron Letters p. 3621 - 3624 (1993)

Update date:2022-08-02

Topics:

Authors:

Soloshonok, Vadim A.

Kirilenko, Alexander G.

Kukhar', Valery P.

Resnati, Giuseppe

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Article abstract of DOI:10.1016/S0040-4039(00)73652-5

The base-catalyzed isomerization of N-benzylimines (or enamines) of β-polyfluoroalkyl-β-ketocarboxylic esters cleanly affords the N-benzylidene derivatives of β-polyfluoro-β-aminocarboxylic esters which are hydrolyzed to corresponding amino acids in high overall yields.

Full text of DOI:10.1016/S0040-4039(00)73652-5

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