Transamination of Fluorinated β-Keto Carboxylic Esters. A Biomimetic Approach to β-Polyfluoroalkyl-β-amino Acids.

DOI: 10.1016/S0040-4039(00)73652-5

Source and publish data:

Tetrahedron Letters p. 3621 - 3624 (1993)

Update date:2022-08-02

Topics:

Authors:

Soloshonok, Vadim A.

Kirilenko, Alexander G.

Kukhar', Valery P.

Resnati, Giuseppe

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)73652-5

The base-catalyzed isomerization of N-benzylimines (or enamines) of β-polyfluoroalkyl-β-ketocarboxylic esters cleanly affords the N-benzylidene derivatives of β-polyfluoro-β-aminocarboxylic esters which are hydrolyzed to corresponding amino acids in high overall yields.

Full text of DOI:10.1016/S0040-4039(00)73652-5

Products guided by the article

Product name:ethyl 4,4-difluoro-3-benzylamino-2-butenoate

Cas No:150618-33-0

R&D Labs maybe for 150618-33-0

Zhaodu Fine Chemical Plant

Contact:86-310-8067016

Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
Jinan Decheng Hemu Medical Technology Co.，Ltd.

Contact:+86-531-68650525

Address:NO.554 Zhengfeng Road High-new Technology Development Zone
Shanghai doly chemical Co.,Ltd

Contact:+86-21-34716221

Address:No.328,WuHe Roard,MinHang,ShangHai China
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.

Contact:+86-25-83767696

Address:14-7 Zhongshan Lu Guluo District, Nanjing
Hubei Honch Pharmaceutical Co.,Ltd

Contact:86-713-7222018

Address:Li Shizhen Pharmaceutical Industry park, Qichun County, Hubei Province,China

Relevant to this article

A convenient method for synthesis of Fmoc-amino acid p-nitroanilides based on isobutyl chloroformate as condensation agent

Doi:10.1016/S0040-4039(00)60527-0
(1993)
Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: Construction of a key linear intermediate

Doi:10.1016/j.tetlet.2015.12.022
(2016)
trans-4-Methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H₃ receptor agonist in vivo

Doi:10.1016/S0960-894X(98)00020-1
(1998)
Use of allylzinc halide as a source of halide: Differential addition of nucleophiles to Ts-aziridines and aldehydes under similar reaction conditions

Doi:10.1016/j.tetlet.2018.12.027
(2019)
Enzymatic resolution of N,N-dialkyl-3-hydroxy-4-pentenamides, unsuccessful in resolution by the Katsuki-Sharpless asymmetric epoxidation

Doi:10.1016/S0957-4166(00)80150-0
(1993)
Merremoside D: De novo synthesis of the purported structure, nmr analysis, and comparison of spectral data

Doi:10.1021/ol403369h
(2014)

Article Doi