Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: Construction of a key linear intermediate

Article abstract of DOI:10.1016/j.tetlet.2015.12.022

Herein, we describe the synthesis of key intermediate (+)-8 as an essential intermediate including full carbon framework for completing the convergent total synthesis of Actinoallolide A (1). (+)-8 was obtained by Negishi and Stille cross coupling from (+)-9, (+)-10 and (-)-11. Stereo-divergent preparation of two similar units, consisting of three consecutive stereocenters, facilitated the synthesis of (+)-10 and (-)-11.