Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains

DOI: 10.1016/0223-5234(93)90147-7

Source and publish data:

European Journal of Medicinal Chemistry p. 297 - 311 (1993)

Update date:2022-08-04

Topics:

Authors:

Giordano, C

Calabretta, R

Gallina, C

Consalvi, V

Scandurra, R

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(93)90147-7

Twenty-four 1-peptidyl-2-haloacetyl hydrazines which can be considered azapeptide halomethanes were synthesized and tested as models of cathepsin B, calpain I and calpain II inhibitors.Reagents designed for cathepsin B inactivation include Z-Tyr, Z-Tyr(I)

Full text of DOI:10.1016/0223-5234(93)90147-7

Products guided by the article

Product name:1-(N-Z-L-leucyl-L-leucyl)-2-(4-hydroxybenzal) hydrazone

Cas No:150650-91-2

R&D Labs maybe for 150650-91-2

Chengdu Green Young Biopharmaceutical INC

Contact:+86-28-85337952

Address:1-B-26,Tianhe Industry Park, No.1480 of Tianfu Road,Chengdu,P.R.China,610000
Wuxi Morality Chemical Co., Ltd(expird)

Contact:

Address:B/7F, 321th WuYun Rd, Wanda Plaza, Wuxi City, 214174, China
Jiangxi Hessence Chemicals Co., Ltd.

Contact:+86 796 3511924

Address:Chengxi Industrial Park, Jishui County, Jiangxi Province 331600 China.
Zhejiang Allied Chemical Co.,Ltd

Contact:18967038207

Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Jingzhou TianHe Sci&Tech Chemical Co., Ltd.

Contact:86-716-8331612

Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province

Relevant to this article

Rapid and large-scale synthesis of bare Co₃O₄ porous nanostructures from an oleate precursor as superior Li-ion anodes with long-cycle lives

Doi:10.1039/c6dt02136k
(2016)
Synthesis and preliminary in vitro biological activity of non-steroidal cytotoxic estrogens designed for the treatment of breast cancer

Doi:10.1139/v93-171
(1993)
Total synthesis of nephritogenic glycopeptide, nephritogenoside

Doi:10.1016/S0040-4039(00)74132-3
(1992)
A simple, efficient, regioselective and one-pot preparation of N-hydroxy- and N-O-protected hydroxyindoles via cycloaddition of nitrosoarenes with alkynes. Synthetic scope, applications and novel by-products

Doi:10.1016/j.tet.2013.10.072
(2013)
A direct synthesis of a bifunctional chelating agent for radiolabeling proteins

Doi:10.1016/S0040-4039(00)79202-1
(1993)
Highly selective oxidative cross-coupling of 2-naphthol derivatives with chiral copper(I)-bisoxazoline catalysts

Doi:10.1016/j.tetlet.2005.06.098
(2005)

Article Doi