Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains

DOI: 10.1016/0223-5234(93)90147-7

Source and publish data:

European Journal of Medicinal Chemistry p. 297 - 311 (1993)

Update date:2022-08-04

Topics:

Authors:

Giordano, C

Calabretta, R

Gallina, C

Consalvi, V

Scandurra, R

et al. et al.

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Article abstract of DOI:10.1016/0223-5234(93)90147-7

Twenty-four 1-peptidyl-2-haloacetyl hydrazines which can be considered azapeptide halomethanes were synthesized and tested as models of cathepsin B, calpain I and calpain II inhibitors.Reagents designed for cathepsin B inactivation include Z-Tyr, Z-Tyr(I)

Full text of DOI:10.1016/0223-5234(93)90147-7

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