Tetrahedron Letters p. 3691 - 3694 (1993)
Update date:2022-08-04
Topics:
Brechbiel, Martin W.
McMurry, Thomas J.
Gansow, Otto A.
A convenient synthesis of a bifunctional derivative of the ligand NOTA is described. The synthesis offers advantages over current literature methods for making similar molecules by starting with the easily prepared ortho-amide of 1,4,7-triazacyclanonane which can be sequentially alkylated to provide a bifunctional NOTA derivative in 9% yield overall. The replacement of preparative HPLC with simple ion-exchange chromatography provides analytically pure ligand suitable for clinical applications.
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Doi:10.1246/cl.1993.1109
(1993)Doi:10.1002/hlca.19930760426
(1993)Doi:10.1016/S0957-4166(00)80363-8
(1993)Doi:10.1021/ja00884a011
(1963)Doi:10.1021/jo00078a023
(1993)Doi:10.1021/jacs.7b05165
(2017)
