An efficient synthesis of an angiotensin II antagonist (A-81988)

Article abstract of DOI:10.1080/00397919308009863

A new and efficient synthesis of A-81988, an angiotensin II antagonist, is described. The preparation utilizes a novel method for tetrazole formation from nitriles requiring trimethylsilyl azide and a catalytic amount of dialkyltin oxide.

Full text of DOI:10.1080/00397919308009863

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Synthetic Communications: An
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An Efficient Synthesis of an
Angiotensin II Antagonist
(A-81988)
Francis A. J. Kerdesky a , Anthony Haight a , B. A.
Narayanan a , Carl W. Nordeen a , David Scarpetti a
Louis S. Seif a , Steven Wittenberger a & Howard E.
Morton a
,
a Process Research, Department 45L ,
Pharmaceutical Products Division Abbott
Laboratories , Abbott Park, Illinois, 60064
Published online: 16 Feb 2007.
To cite this article: Francis A. J. Kerdesky , Anthony Haight , B. A. Narayanan ,
Carl W. Nordeen , David Scarpetti , Louis S. Seif , Steven Wittenberger & Howard
E. Morton (1993) An Efficient Synthesis of an Angiotensin II Antagonist (A-81988),
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 23:14, 2027-2039, DOI: 10.1080/00397919308009863
To link to this article: http://dx.doi.org/10.1080/00397919308009863
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