A facile synthesis of 7,10-dideoxy taxol and 7-epi-10-deoxy taxol

DOI: 10.1016/S0040-4039(00)91810-0

Source and publish data:

Tetrahedron Letters p. 6845 - 6848 (1993)

Update date:2022-09-26

Topics:

Authors:

Chen Chen

Wei Wei

Vyas Vyas

Doyle Doyle

Farina Farina

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Article abstract of DOI:10.1016/S0040-4039(00)91810-0

7,10-Dideoxy taxol 2 was prepared from baccatin III in 4 steps via the Barton deoxygenation reaction. Similarly, 7-epi-10-deoxy taxol 3 was prepared in one step from 7-epi taxol in high yield. The key reaction was the tributyltin hydride-mediated directed reduction of the C₁₀ acetate.

Full text of DOI:10.1016/S0040-4039(00)91810-0

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