An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid

DOI: 10.1021/jm00035a018

Source and publish data:

Journal of Medicinal Chemistry p. 1371 - 1377 (1994)

Update date:2022-08-04

Topics:

Authors:

Chamberlain

Biron Biron

Dornsife

Averett Averett

Beauchamp

Koszalka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00035a018

The racemic isosteric phosphonate of ganciclovir monophosphate (BW2482U89, SR3745, [3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid, 1) has potent and selective in vitro activity against human cytomegalovirus. An enant

Full text of DOI:10.1021/jm00035a018

Products guided by the article

Product name:(R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

Cas No:150943-39-8

R&D Labs maybe for 150943-39-8

Huangshan Honghui Pharm Technology Co., Ltd.(expird)

website:http://www.honghuichem.com

Contact:18855958372

Address:Qingshan Wan No.1,Nanyuan Kou,SheXian Huangshan City,Anhui Province
LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:+86-25-58409506

Address:Chungking Express Nos.36 Nathan Road，Kowloon, HK
Du-Hope International Group

website:http://www.np-chem.com

Contact:0086-25-52346877

Address:199, Jian Ye Road, Nanjing, China
JIEJIE GROUP CO.,LTD.

Contact:+86 021-51698675

Address:1701, Jielong Plaza, No.618 Pingliang Rd, ShangHai,China
Sinoway International (Jiangsu) Co., Ltd.

Contact:+86-25-86630167

Address:17 Beijing Road (West), Nanjing, China

Relevant to this article

WAGNER-MEERWEIN REARRANGEMENT OF THE HOMOCUBYLCARBINYL SYSTEM, AND X-RAY STRUCTURE OF 1-BROMO-4,4-DIPHENYL-5-METHOXYPENTACYCLO-(5.3.0.0^2.6.0^3.9.0^5.8)DECAN-10-ONE ETHYLENE KETAL

Doi:10.1016/S0040-4020(01)87614-6
(1986)
Copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes

Doi:10.1021/ol403263c
(2014)
Synthesis of Selectively N-Functionalized Polyamine Derivatives

Doi:10.1002/hlca.19930760412
(1993)
Selective transition-metal-free vicinal cis-dihydroxylation of saturated hydrocarbons

Doi:10.1039/C6SC03055F
(2016)
Reaction of malondialdehyde with amine neurotransmitters. Formation and oxidation chemistry of fluorescent 1,4-dihydropyridine adducts

Doi:10.1016/0040-4020(95)00552-J
(1995)
Mechanism of Arylation of Nucleophiles by Aryllead Triacetates. Part 1. Exclusion of a Pathway involving Aryl Free Radicals

Doi:10.1039/P19930001673
(1993)

Article Doi