An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid

DOI: 10.1021/jm00035a018

Source and publish data:

Journal of Medicinal Chemistry p. 1371 - 1377 (1994)

Update date:2022-08-04

Topics:

Authors:

Chamberlain

Biron Biron

Dornsife

Averett Averett

Beauchamp

Koszalka

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Article abstract of DOI:10.1021/jm00035a018

The racemic isosteric phosphonate of ganciclovir monophosphate (BW2482U89, SR3745, [3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid, 1) has potent and selective in vitro activity against human cytomegalovirus. An enant

Full text of DOI:10.1021/jm00035a018

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