Stereodivergent synthesis of β-amino-α-hydroxyphosphonic acid derivatives by Lewis acid mediated stereoselective hydrophosphonylation of α-amino aldehydes

Article abstract of DOI:10.1016/S0957-4166(00)80325-0

The highly diastereoselective synthesis of β-amino-α-hydroxyphosphonic acid derivatives was achieved by Lewis acid mediated hydrophosphonylation of α-dibenzylamino aldehyde. Diastereofacial differentiation could be controlled in either a chelation or a no