Organic Letters p. 174 - 177 (2014)
Update date:2022-08-04
Topics:
Miller, Steven P.
Zhong, Yong-Li
Liu, Zhijian
Simeone, Michael
Yasuda, Nobuyoshi
Limanto, John
Chen, Zheng
Lynch, Joseph
Capodanno, Vincent
Compound 1, a potent and irreversible inhibitor of β-lactamases, is in clinical trials with β-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.
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