TSAO Analogues. 3. Synthesis and Anti-HIV-1 Activity of 2',5'-Bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl 3'-Spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) Purine and Purine-Modified Nucleosides

DOI: 10.1021/jm00074a003

Source and publish data:

Journal of Medicinal Chemistry p. 3230 - 3239 (1993)

Update date:2022-08-04

Topics:

Authors:

Velazquez, Sonsoles

San-Felix, Ana

Perez-Perez, Maria Jesus

Balzarini, Jan

Clercq, Erik De

Camarasa, Maria Jose

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Article abstract of DOI:10.1021/jm00074a003

Several purine and purine-modified analogues of the new lead anti-HIV-1 agent <<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>thymine>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide)(TSAO-T) have been prepared and evaluated as inhibit

Full text of DOI:10.1021/jm00074a003

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