TSAO Analogues. 3. Synthesis and Anti-HIV-1 Activity of 2',5'-Bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl 3'-Spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) Purine and Purine-Modified Nucleosides

Article abstract of DOI:10.1021/jm00074a003

Several purine and purine-modified analogues of the new lead anti-HIV-1 agent <<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>thymine>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide)(TSAO-T) have been prepared and evaluated as inhibit