Journal of Medicinal Chemistry p. 3197 - 3201 (1993)
Update date:2022-08-04
Topics:
Rosen, Terry
Seeger, Thomas F.
McLean, Stafford
Desai, Manoj C.
Guarino, Karen J.
et al.
The synthesis of a highly potent and selective NK1 receptor antagonist radioligand, <3H>-cis-3-<(2-methoxybenzyl)amino>-2-phenylpiperidine (6a) is described.The in vitro binding pharmacology and autoradiographic distribution of 6a in guinea pig brain following peripheral administration are also reported.
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