Studies on nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological evaluation of pyrazolo [1,5-b][1,2,4]triazole derivatives with alkyl substituents

DOI: 10.1248/cpb.46.69

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 69 - 78 (1998)

Update date:2022-07-30

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Authors:

Okazaki, Toshio

Suga, Akira

Watanabe, Toshihiro

Kikuchi, Kazumi

Kurihara, Hiroyuki

Shibasaki, Masayuki

Fujimori, Akira

Inagaki, Osamu

Yanagisawa, Isao

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Article abstract of DOI:10.1248/cpb.46.69

Alkyl-substituted pyrazolo[1,5-b][1,2,4]triazole derivatives were synthesized and evaluated for activity as angiotensin II receptor antagonists. Molecules with the (methylbiphenylyl)tetrazole moiety at N-5 were the preferred compounds. Ethyl substitutions

Full text of DOI:10.1248/cpb.46.69

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