Studies on nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological evaluation of pyrazolo [1,5-b][1,2,4]triazole derivatives with alkyl substituents

DOI: 10.1248/cpb.46.69

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 69 - 78 (1998)

Update date:2022-07-30

Topics:

Authors:

Okazaki, Toshio

Suga, Akira

Watanabe, Toshihiro

Kikuchi, Kazumi

Kurihara, Hiroyuki

Shibasaki, Masayuki

Fujimori, Akira

Inagaki, Osamu

Yanagisawa, Isao

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.46.69

Alkyl-substituted pyrazolo[1,5-b][1,2,4]triazole derivatives were synthesized and evaluated for activity as angiotensin II receptor antagonists. Molecules with the (methylbiphenylyl)tetrazole moiety at N-5 were the preferred compounds. Ethyl substitutions

Full text of DOI:10.1248/cpb.46.69

NII-Electronic Library Service

Products guided by the article

Product name:6-methyl-2-propyl-1H-pyrazolo[1,5-b][1,2,4]triazole

Cas No:151406-56-3

R&D Labs maybe for 151406-56-3

Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)

Contact:+86-512-69598882

Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China
Taizhou Shengxing Chempharm Co.,Ltd

Contact:+86-576-88516600

Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China
Shanghai Massive Chemical Technology Co., Ltd.

website:http://www.massivechem.com/

Contact:+86 21 34943721

Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Radiant Pharma & Tech Company

Contact:+86-511-88790000

Address:338 North Yushan Rd, Zhenjiang, Jiangsu 212016
Jingzhou TianHe Sci&Tech Chemical Co., Ltd.

Contact:86-716-8331612

Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province

Relevant to this article

Pyrolysis of β,γ,β'-trioxo phosphorus ylides: Convenient synthesis of symmetrical and unsymmetrical diacylalkynes

Doi:10.1016/S0040-4039(00)73898-6
(1993)
Rapid total synthesis of (±)trigonoliimine A via a Strecker/Houben-Hoesch sequence

Doi:10.1021/ol303344d
(2013)
An Expeditious Enantiodivergent Synthesis of Chiral Oxepanes from D-Glucose by the Application of Intramolecular 1,3-Dipolar Nitrone Cycloaddition

Doi:10.1016/S0040-4039(00)73642-2
(1993)
Total synthesis of aphadilactones A-D

Doi:10.1021/jo501117k
(2014)
A modification of a conventional technique for the synthesis of hydrazones of racemic carbonyls: Prevention of spontaneous chiral inversion

Doi:10.1039/c5ra19904b
(2015)
Electrolytic Oxidation of Ketones in a Methanolic Solution of NaCN in the Presence of Catalytic Amounts of KI

Doi:10.1021/jo00075a010
(1993)

Article Doi