O-Alkylation des 1-F-alkyl-2-fluoroethanols: synthese d'acetals et d'ethers vinyliques F-alkyles

Article abstract of DOI:10.1016/0022-1139(93)02952-B

O-Alkylation of 1-F-alkyl-2-fluoroethanols may be achieved at 25-40 deg C by the action of halogenated derivatives in a basic medium and in the presence of a phase-transfer catalyst.This reaction is followed in most cases by dehydrofluorination to yield polyfluorinated vinyl acetals when the alkylating agent is dichloromethane and F-alkylated vinyl ethers when it is a monohalogenated derivative.With some other alkylating agents (iodomethane, 3-bromocyclohexene, 1-bromo-3-methylbut-2-ene and 1-bromobut-2-ene), partial or no dehydrofluorination is achieved in the homogeneous phase by the action of KOH in triethylene glycol at 100 deg C.