Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents

Article abstract of DOI:10.1021/jm00074a026

A series of 2,4-diamino-5-methyl-6-(anilinomethyl)pyrido[2,3- d]pyrimidines 4-9 were synthesized as 5-deaza nonclassical antifolates containing trimethoxy, dichloro-, or trichlorophenyl substitutions and a N- H, N-CH₃, or N-CHO at the 10-positi