European Journal of Medicinal Chemistry p. 419 - 425 (1993)
Update date:2022-08-03
Topics:
Corona, L Del
Signorelli, G
Pinzetta, A
Coppi, G
A series of amino-halogen-N-<2-aminoethyl> benzamides was synthesized and evaluated for enhancing gastric emptying.Compared to metoclopramide, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic. substituted benzamides / gastrokinetic activity
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Doi:10.1246/bcsj.67.1130
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