Design, Synthesis, and Biological Activity of Methoctramine-Related Tetraamines Bearing an 11-Acetyl-5,11-dihydro-6H-pyridobenzodiazepin-6-one Moiety:Structural Requirements for Optimum Occupancy of Muscarine Receptor Subtypes As Revealed by S

DOI: 10.1021/jm00046a021

Source and publish data:

Journal of Medicinal Chemistry p. 3363 - 3372 (1994)

Update date:2022-08-03

Topics:

Authors:

Minarini, Anna

Bolognesi, Maria L.

Budriesi, Roberta

Canossa, Marco

Chiarini, Alberto

et al. et al.

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Article abstract of DOI:10.1021/jm00046a021

Tetraamines 5-13 and diamines 14-17 as well as monoamine 18 were synthesized, and their biological profiles at muscarinic receptor subtypes were assessed by functional experiments in isolated guinea pig left atrium (M₂) and ileum (M₃

Full text of DOI:10.1021/jm00046a021

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