Hydroxamic acids as potent inhibitors of endothelin-converting enzyme from human bronchiolar smooth muscle

Article abstract of DOI:10.1021/jm00012a011

Hydroxamic acids 6a-h, derived from malonyl amino acids, and 25a-d, derived from succinyl amino acids, were synthesized as inhibitors of human bronchiolar smooth muscle endothelin-converting enzyme (HBSM ECE). Several unexpected side reactions were discov