Tetrahedron Letters p. 5975 - 5978 (1998)
Update date:2022-08-02
Topics:
Ikeda, Shuji
Saito, Isao
Sugiyama, Hiroshi
A facile method for the synthesis of puromycin-tethered oligonucleotides at the 3'-end is described. The method utilizes a novel CPG support derived from commercially available puromycin. Puromycin-tethered DNA and RNA oligomers were synthesized using a puromycin-tethered CPG support by the usual protocol for automated DNA and RNA synthesis.
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