Facile synthesis of puromycin-tethered oligonucleotides at the 3'-end

DOI: 10.1016/S0040-4039(98)01226-X

Source and publish data:

Tetrahedron Letters p. 5975 - 5978 (1998)

Update date:2022-08-02

Topics:

Authors:

Ikeda, Shuji

Saito, Isao

Sugiyama, Hiroshi

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Article abstract of DOI:10.1016/S0040-4039(98)01226-X

A facile method for the synthesis of puromycin-tethered oligonucleotides at the 3'-end is described. The method utilizes a novel CPG support derived from commercially available puromycin. Puromycin-tethered DNA and RNA oligomers were synthesized using a puromycin-tethered CPG support by the usual protocol for automated DNA and RNA synthesis.

Full text of DOI:10.1016/S0040-4039(98)01226-X

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