The synthesis of (R)-γ-phenyl-γ-(trifluoromethyl)-butyrolactone and (2R,3S)-1,1,1-trifluoro-2-methoxy-2-phenyl-3,4-epoxybutane in homochiral forms

Article abstract of DOI:10.1016/S0957-4166(00)80378-X

(R)-γ-Phenyl-γ-(trifluoromethyl)-butyrolactone (1) and (2R,3S)-1,1,1-trifluoro-2-methoxy-2-phenyl-3,4-epoxybutane (2) have been prepared in high optical purity from the tertiary (S)-(3)-acetate which was resolved using the lipase from Candida cylindracea.