Synthesis of structural analogs of leukotriene B4 and their receptor binding activity

Article abstract of DOI:10.1021/jm00074a012

Structural analogs of leukotriene B₄ (LTB₄) were designed using a preferred conformation of LTB₄ (1). Appending an aromatic ring scaffold between LTB₄ carbons 7 and 11 led to quinoline analogs 3 and 15. A simila