Design and synthesis of potent antitumor 5,4'-diaminoflavone derivatives based on metabolic considerations

DOI: 10.1021/jm9700326

Source and publish data:

Journal of Medicinal Chemistry p. 1894 - 1900 (1997)

Update date:2022-08-04

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Authors:

Akama, Tsutomu

Ishida, Hiroyuki

Shida, Yasushi

Kimura, Uichiro

Gomi, Katsushige

Saito, Hiromitsu

Fuse, Eiichi

Kobayashi, Satoshi

Yoda, Nobuyuki

Kasai, Masaji

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Article abstract of DOI:10.1021/jm9700326

Recently, we reported that 5,4'-diaminoflavone (1) exhibits potent and specific growth-inhibitory activity against the estrogen receptor (ER)- positive human breast cancer cell line MCF-7. However, when compound 1 was incubated with S-9 mix, its metabolit

Full text of DOI:10.1021/jm9700326

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