Studies in Biomimetic Polyether Synthesis: Synthesis of an A-Ring Subunit of Etheromycin.

Article abstract of DOI:10.1016/S0040-4039(00)79360-9

The β-hydroxyketones 7, 20 and 22 were prepared by stereocontrolled aldol reactions of (S)- and (R)-18 with the enal 8.Acetonide hydrolysis gave the bicyclic acetals 23-25, while the benzoate 26 gave the tetrahydropyran 6, corresponding to an A-ring subun