Enantiomerically Pure Dimethyl (2S)-N-(9-Phenylfluoren-9-yl)-3,4-didehydroglutamate as Chiral Educt. Chirospecific Synthesis of (+)-5-O-Carbamoylpolyoxamic Acid and 3-Alkylglutamates

Article abstract of DOI:10.1021/jo00077a015

We report here a short and efficient synthesis (four steps, 78percent overall yield) of dimethyl (2S)-N-(9-phenylfluoren-9-yl)-3,4-didehydroglutamate (1) in enantiomerically pure form from L-glutamic acid.The C-C double bond in 1 was introduced by selecti