CC-1065 Functional Analogues Possessing Different Electron-Withdrawing Substituents and Leaving Groups: Synthesis, Kinetics, and Sequence Specificity of Reaction with DNA and Biological Evaluation

Article abstract of DOI:10.1021/jm00078a005

Antitumor agent CC-1065 functional analogues possessing different electron-withdrawing substituents and leaving groups have been synthesized.The extent and relative rates of DNA cleavage following alkylation by these CPI structures and thermal treatment w