Synthesis of Thiazoloisoindoles by Intramolecualar Cycloaddition-Elimination Reactions of 4-Methyl-5-(substituted)imino-Δ2-1,2,3,4-thiatriazolines

Article abstract of DOI:10.1016/S0040-4020(01)85758-6

Fused thiazolidine 11 and thiazoline derivatives 19a-c are obtained by intramolecular cycloaddition-elimination reactions of appropriately substituted 5-iminothiatriazolines 10 and 18a-c.The incorporation of a sidechain phenyl group excercises a favorable effect on cyclization since no reaction is observed with 25.Comparable intermolecular reactions also fail to occur.