Brush-Border-Enzyme-Mediated Intestine-Specific Drug Delivery. Amino Acid Prodrugs of 5-Aminosalicylic Acid

DOI: 10.1021/jm00078a009

Source and publish data:

Journal of Medicinal Chemistry p. 4201 - 4207 (1993)

Update date:2022-08-02

Topics: Enzyme-Mediated

Authors:

Pellicciari, Roberto

Garzon-Aburbeh, Aaron

Natalini, Benedetto

Marinozzi, Maura

Clerici, Carlo

et al. et al.

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Article abstract of DOI:10.1021/jm00078a009

5-Aminosalicylic acid (5-ASA) is the active principle of a number of preparations aimed at the treatment of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, but its efficacy is limited by early absorption and metabolism.The pos

Full text of DOI:10.1021/jm00078a009

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