Bioorganic and Medicinal Chemistry Letters p. 177 - 180 (2014)
Update date:2022-09-26
Topics:
Schroder, Tenna Juul
Christensen, Soren
Lindberg, Samsa
Langgard, Morten
David, Laurent
Maltas, Philip J.
Eskildsen, Jorgen
Jacobsen, Jan
Tagmose, Lena
Simonsen, Klaus Baek
Biilmann Ronn, Lars Christian
De Jong, Inge E.M.
Malik, Ibrahim J.
Karlsson, Jens-Jakob
Bundgaard, Christoffer
Egebjerg, Jan
Stavenhagen, Jeffrey B.
Strandbygard, Dorthe
Thirup, Soren
Andersen, Jacob Lauwring
Uppalanchi, Srinivas
Pervaram, Sridhar
Kasturi, Shiva Prasad
Eradi, Pradheep
Sakumudi, Durga Rao
Watson, Stephen P.
The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.
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