Total Synthesis and Biological Properties of Novel Antineoplastic (Chloromethyl)furanoindolines: An Asymmetric Hydroboration Mediated Synthesis of the Alkylation Subunits

DOI: 10.1021/jm00028a005

Source and publish data:

Journal of Medicinal Chemistry p. 232 - 239 (1994)

Update date:2022-09-26

Topics:

Authors:

Mohamadi, Fariborz

Spees, Michael M.

Staten, Gilbert S.

Marder, Philip

Kipka, Julia K.

et al. et al.

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Article abstract of DOI:10.1021/jm00028a005

1,2-Dihydro-1-(chloromethyl)-5-hydroxy-8-methyl-3H-furano<3,2-e>indole (CFI) as a novel replacement of the cyclopropylpyrroloindoline (CPI) alkylation subunit of CC-1065, U-71184, and U-73975 (adozelesin) has been synthesized and incorporated into a serie

Full text of DOI:10.1021/jm00028a005

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