Journal of Pharmaceutical Sciences p. 571 - 576 (1994)
Update date:2022-08-04
Topics:
Waller
Wyrick
Park
Kemp
Smith
It has been demonstrated that agents which inhibit chloride influx and, therefore, lower intracellular chloride levels in the astrocyte, a major cell type in the cerebral gray matter, inhibit astrocytic swelling in vitro and in vivo. Herein, we report additional examples of a series of [(N-alkyl-1,3- dihydro-1-oxoisoindolin-5-yl)oxy]alkanoic acids and their effects upon ion transport in primary rat astrocyte cultures. The 4-chloro-substituted 1- oxoisoindolines demonstrated superior astrocytic chloride influx inhibitory activity as compared to the 6-chloro and non-chlorinated analogs. The four- carbon acid side chain derivatives were more active than the three- and two- carbon analogs. The pharmacological profile of these compounds was examined with respect to inhibition of the Cl--Cl-/Cl--HCO3- anion exchanger and Na+-K+-2Cl cotransport mechanisms in glia, and the compounds were found to exhibit a similar profile to that of furosemide by inhibiting both transporters.
View MoreZhengzhou Institute of Chiral Pharmer Research Co., Ltd.
Contact:86-371-55219111
Address:15 Floor, 2 Building, Central China Technovalley, Zhongyuan West Road
SPRING CHEMICAL INDUSTRY CO.,LTD
Contact:86-187-66672125
Address:linchi industry park.zouping
website:http://www.mingchem.com/en/index
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Shanghai KFSL Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-39971718
Address:859 jiadingchengliu shanghai
Naturalin Bio-Resource Co., Ltd
website:http://www.naturalin.com
Contact:+86-0731-84430651
Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Doi:10.1055/s-0033-1338984
(2013)Doi:10.1021/jo401365p
(2013)Doi:10.1002/ejic.201500310
(2015)Doi:10.1016/0008-6215(94)00369-Q
(1995)Doi:10.2533/000942904777678181
(2004)Doi:10.1055/s-0033-1339849
(2013)