Journal of Pharmaceutical Sciences p. 571 - 576 (1994)
Update date:2022-08-04
Topics:
Waller
Wyrick
Park
Kemp
Smith
It has been demonstrated that agents which inhibit chloride influx and, therefore, lower intracellular chloride levels in the astrocyte, a major cell type in the cerebral gray matter, inhibit astrocytic swelling in vitro and in vivo. Herein, we report additional examples of a series of [(N-alkyl-1,3- dihydro-1-oxoisoindolin-5-yl)oxy]alkanoic acids and their effects upon ion transport in primary rat astrocyte cultures. The 4-chloro-substituted 1- oxoisoindolines demonstrated superior astrocytic chloride influx inhibitory activity as compared to the 6-chloro and non-chlorinated analogs. The four- carbon acid side chain derivatives were more active than the three- and two- carbon analogs. The pharmacological profile of these compounds was examined with respect to inhibition of the Cl--Cl-/Cl--HCO3- anion exchanger and Na+-K+-2Cl cotransport mechanisms in glia, and the compounds were found to exhibit a similar profile to that of furosemide by inhibiting both transporters.
View Morewebsite:http://www.win-winchemical.com
Contact:0086-577-64498589
Address:6F, No. 396 Xingping Road, Longwan Industrial Zone, Wenzhou City, Zhejiang, 325000 P.R.China
SINO Industries Company Limited(expird)
Contact:86-29-85369724
Address:No.111, Jiefang Road, Xi’an, China
Fusilin chemical science & technology co., ltd.
Contact:532-80698166/86057573, +86-400-669-7885
Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong
Liaoyang hengye Chemical Co., Ltd.
Contact:86-419-5850866
Address:North Old Xiaoxiao Road,Yantai District, Dengta, Liaoyang, Liaoning, China
NINGBO PANGS CHEM INT’L CO., LTD.
Contact:+86-0574-27666801
Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Doi:10.1055/s-0033-1338984
(2013)Doi:10.1021/jo401365p
(2013)Doi:10.1002/ejic.201500310
(2015)Doi:10.1016/0008-6215(94)00369-Q
(1995)Doi:10.2533/000942904777678181
(2004)Doi:10.1055/s-0033-1339849
(2013)