Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity

DOI: 10.1021/jm00041a022

Source and publish data:

Journal of Medicinal Chemistry p. 2421 - 2436 (1994)

Update date:2022-08-04

Topics:

Authors:

Diana Diana

Volkots Volkots

Nitz Nitz

Bailey Bailey

Long Long

Vescio Vescio

Aldous Aldous

Pevear Pevear

Dutko Dutko

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Article abstract of DOI:10.1021/jm00041a022

A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the MIC₈₀, the concentration which inhibits 80% or 12 of the serotypes tested, was determined. Homologation of the alkyl

Full text of DOI:10.1021/jm00041a022

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Product name:acetic acid, α-methyl-<3-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-1,2,4-oxadiazol-5-yl>methyl ester

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