Mechanism of the formation in vivo of α-phenyl-γ-lactones in the glutethimide series

DOI: 10.1016/0223-5234(93)90090-2

Source and publish data:

European Journal of Medicinal Chemistry p. 593 - 600 (1993)

Update date:2022-08-03

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Authors:

Al-Tarakji-Khalfh

Cave Cave

Menager Menager

Legras Legras

Combet Farnoux

Lafont Lafont

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Article abstract of DOI:10.1016/0223-5234(93)90090-2

The isolation of γ-lactones from the urines of humans or animals treated with glutethimide or aminoglutethimide required an explanation. The question was studied on the glutethimide model. Potential metabolites such as β-hydroxymetabolite, γ-lactone amide

Full text of DOI:10.1016/0223-5234(93)90090-2

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