Dramatic Differences in the Effectiveness among Various Coupling Methods in the Synthesis of Peptides Containing α,α-Diphenylglycine

Article abstract of DOI:10.1246/cl.1993.1583

Both couplings of N-benzyloxycarbonyl-α,α-diphenylglycine (Z-Dph) with methyl esters of various amino acids (AA-OMe) and Z-AA with Dph-OMe by various methods can yield Z-Dph-AA-OMe and Z-AA-Dph-OMe, respectively.Yields of the dipeptides remarkably differ