Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents

DOI: 10.1016/S0960-894X(99)00537-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3063 - 3068 (1999)

Update date:2022-07-30

Topics:

Authors:

Hagihara, Masahiko

Kashiwase, Hiroto

Katsube, Tetsushi

Kimura, Tomio

Komai, Tomoaki

Momota, Kenji

Ohmine, Toshinori

Nishigaki, Takashi

Kimura, Satoshi

Shimada, Kaoru

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00537-5

Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds

Full text of DOI:10.1016/S0960-894X(99)00537-5

Products guided by the article

Product name:8-(Difluoromethoxy)-1-ethyl-6-fluoro-4-oxo-7-[4-(2-pyrimidinyl)piperazin-1-yl]-1,4-dihydroquinoline-3-carboxylic acid

Cas No:153468-37-2

R&D Labs maybe for 153468-37-2

Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
LIANYUNGANG YC FINE CHEMICAL CO., LTD

Contact:+86-518-858 99188

Address:Shangdong Modern Bldg, South Greenpark Road, Lianyungang, Jiangsu Pro. China
Shanghai He Yang International Trading Co., Ltd.

Contact:+86-21-52043598

Address:Room 816, Blag.5, No.58 Huachi Road
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.

Contact:86-022-66880623

Address:FINANCIAL STREET WEST BLK 7, #308, NO.52 XINCHENG WEST ROAD, TEDA, TIANJIN, P.R.CHINA
Pale Palm Imex

Contact:+36(21)2523420

Address:Head office: 1102 Budapest, SZENT LASZLO TER 24/B. 1/1., HUNGARY / CHINA

Relevant to this article

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

Doi:10.1039/C8OB03088J
(2019)
D-gluconhydroximo-1,5-lactam and related N-arylcarbamates. Theoretical calculations, structure, synthesis, and inhibitory effect on β-glucosidases

Doi:10.1002/hlca.19930760723
(1993)
Doi:10.1016/S0040-4039(00)90786-X
(1967)
Doi:10.1007/BF00846599
()
Doi:10.1007/BF00911842
()
Hybrid macromolecular antioxidants based on hydrophilic polymers and sterically hindered phenols

Doi:10.1007/s11172-007-0117-x
(2007)

Article Doi