Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents

DOI: 10.1016/S0960-894X(99)00537-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3063 - 3068 (1999)

Update date:2022-07-30

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Authors:

Hagihara, Masahiko

Kashiwase, Hiroto

Katsube, Tetsushi

Kimura, Tomio

Komai, Tomoaki

Momota, Kenji

Ohmine, Toshinori

Nishigaki, Takashi

Kimura, Satoshi

Shimada, Kaoru

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Article abstract of DOI:10.1016/S0960-894X(99)00537-5

Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds

Full text of DOI:10.1016/S0960-894X(99)00537-5

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Product name:8-(Difluoromethoxy)-1-ethyl-6-fluoro-4-oxo-7-[4-(2-pyrimidinyl)piperazin-1-yl]-1,4-dihydroquinoline-3-carboxylic acid

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