Synthesis and antibacterial activity of new quinolones containing a 7-[3- (1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential

Article abstract of DOI:10.1021/jm00032a005

A series of the R and S isomers of 7-[3-(1-amino-1-methylethyl)-1- pyrrolidinyl]-1,4-dihydro-4-oxoquinoline- and 1,8-naphthyridine-3-carboxylic acids was prepared to determine the effect on potency of the two methyl groups adjacent to the distal nitrogen