The synthesis of a C9-C17 fragment of discodermolide

DOI: 10.1016/S0040-4039(00)61480-6

Source and publish data:

Tetrahedron Letters p. 8163 - 8166 (1993)

Update date:2022-09-26

Topics:

Authors:

Evans Evans

Golec Golec

Gillespie

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Article abstract of DOI:10.1016/S0040-4039(00)61480-6

The asymmetric synthesis of a synthetically useful fragment corresponding to the C₉-C₁₇ region of the immunosuppressant lactone discodermolide is reported. The route incorporates the use of an unsaturated lactone to provide a trisubstituted olefin with absolute control of geometry.

Full text of DOI:10.1016/S0040-4039(00)61480-6

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