
Tetrahedron Letters p. 8163 - 8166 (1993)
Update date:2022-09-26
Topics:
Evans
Golec
Gillespie
The asymmetric synthesis of a synthetically useful fragment corresponding to the C9-C17 region of the immunosuppressant lactone discodermolide is reported. The route incorporates the use of an unsaturated lactone to provide a trisubstituted olefin with absolute control of geometry.
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Doi:10.1039/c3dt52655k
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(1993)