Tetrahedron Asymmetry p. 2025 - 2026 (1993)
Update date:2022-07-30
Topics:
Provencher
Wynn
Jones
Krawczyk
The dimensions of the large hydrophobic pocket (H(L)) of the active site model of pig liver esterase (PLE) were probed using a series of aliphatic and phenylic malonates. Results from the hydrolyses of these new unnatural substrates permitted the extension of the H(L) pocket to give the new dimensions of 6.2 x 2.3 x 3.9 A for a total volume of ~56 A3.
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Doi:10.1246/bcsj.66.3113
(1993)Doi:10.1039/c7ob01064h
(2017)Doi:10.1016/S0957-4166(00)80097-X
(1993)Doi:10.1016/S0040-4039(00)79321-X
(1993)Doi:10.1021/jo00124a029
(1995)Doi:10.1021/acs.joc.7b00175
(2017)