Synthesis and biological activity of the neuronal calcium channel blocker 2-amino-1-(2,5-dimethoxyphenyl)-5-trifluoromethyl benzimidazole (NS-649)

DOI: 10.1016/0960-894X(96)00010-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 245 - 248 (1996)

Update date:2022-08-03

Topics:

Authors:

Varming Varming

Christophersen

Moller Moller

Peters Peters

Axelsson

Nielsen Nielsen

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Article abstract of DOI:10.1016/0960-894X(96)00010-8

The substituted benzimidazole, NS-649, has been shown to be a blocker of neuronal calcium channels in patch-clamp studies. NS-649 dose-dependently inhibited release of D-aspartate from cerebellar granule neurons. The neuroprotective effect of this compound in vitro and in vivo models of ischemia was demonstrated.

Full text of DOI:10.1016/0960-894X(96)00010-8

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